Basic information of Il33 :

Official Symbol of Gene	Il33
Species	Mus musculus
Entrez Gene ID	77125
Official Full Name	interleukin 33
Also known as	Il-33; Il1f11; NF-HEV; 9230117N10Rik
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000024810 AllianceGenome:MGI:1924375
Map Location	19; 19 C1
Drug	IL-33
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	female SJL rat
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	29378942
Year	2018
Title	Male-specific IL-33 expression regulates sex-dimorphic EAE susceptibility

Results of multiple sclerosis :

Result	IL-33 expands ILC2s, drives a Th2 response, and diminishes clinical signs of EAE in females.
Mechanism/pathway	Reduced expression of IL-33 leading to a diminished ILC2 response in females underlies sex-dimorphic EAE susceptibility, IL-33 treatment of SJL females should confer protection by activating ILC2s and shifting the pathogenic anti-myelin response to one that is Th2 skewed.