Basic information of Ctla4 :

Official Symbol of Gene	Ctla4
Species	Mus musculus
Entrez Gene ID	12477
Official Full Name	cytotoxic T-lymphocyte-associated protein 4
Also known as	Cd152; Ly-56; Ctla-4
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000026011 AllianceGenome:MGI:88556
Map Location	1 C2; 1 30.58 cM
Drug	AdCTLA (CTLA4-Ig fusion protein)
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	Biozzi ABH (H2dq1) mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	9862327
Year	1998
Title	Local gene therapy with CTLA4-immunoglobulin fusion protein in experimental allergic encephalomyelitis

Results of multiple sclerosis :

Result	The development and intensity of lesion load is delayed and reduced, respectively, in mice receiving AdCTLA and thus correlates well with the clinical profile observed.
Mechanism/pathway	In contrast to some of the stimulating/agonist capabilities of mAb specific for CTLA4, CTLA4-Ig fusion proteins (CTLA4-Ig) appear to act as CD28 antagonists and prevent co-stimulation in vitro and inhibit in vivo T cell priming in a variety of immunological diseases.