Basic information of Cnr2 :
| Official Symbol of Gene | Cnr2 |
| Species | Mus musculus |
| Entrez Gene ID | 12802 |
| Official Full Name | cannabinoid receptor 2 (macrophage) |
| Also known as | CB2; CB-2; CB2-R |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000062585 AllianceGenome:MGI:104650 |
| Map Location | 4; 4 D3 |
| Drug | HUâ€308 |
| Interaction Type | activator |
Sample information of multiple sclerosis:
| Descent | C57BL/6 |
| Disease | EAE |
Literature information of multiple sclerosis :
| Pubmed ID | 25417929 |
| Year | 2014 |
| Title | Activating cannabinoid receptor 2 alleviates pathogenesis of experimental autoimmune encephalomyelitis via activation of autophagy and inhibiting NLRP3 inflammasome |
Results of multiple sclerosis :
| Result | HUâ€308 significantly reduced the peak severity and cumulative clinical score of EAE.Histological examination of the spinal cords was performed at day 17 postimmunization (PI).Compared to vehicle control, HUâ€308 aused a dramatic reduction of leukocyte infiltration in spinal cord. Luxol fast blue staining also revealed less extensive demyelination in HUâ€308â€treated mice than in controls. |
| Mechanism/pathway | Activation of CB2R ameliorate EAE through suppressing key components of the inflammatory process and reducing Th17 differentiation, immune cell accumulation, and microglia activation in the CNS. |
