Basic information of Il2 :
| Official Symbol of Gene | Il2 |
| Species | Rattus norvegicus |
| Entrez Gene ID | 116562 |
| Official Full Name | interleukin 2 |
| Also known as | N/A |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSRNOG00000017348 AllianceGenome:RGD:620047 |
| Map Location | 2q25 |
| Drug | DAB389IL-2 |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | female Lewis rats |
| Disease | EAE |
Literature information of multiple sclerosis :
| Pubmed ID | 23872438 |
| Year | 2013 |
| Title | DAB389IL-2 suppresses autoimmune inflammation in the CNS and inhibits T cell-mediated lysis of glial target cells |
Results of multiple sclerosis :
| Result | DAB(389)IL-2 inhibited infiltration of CD4(+), CD8(+), CD25(+) and TCR αβ(+) associated mononuclear cells and inflammatory macrophages in the spinal cord on day 13 post-immunization, at the peak of disease.Gene expression study showed that DAB(389)IL-2 treatment suppressed TNF-α and IFN-γ as well as IL-10 cytokine gene expression in the spinal cord of rats with EAE on day 13.DAB(389)IL-2 in vitro treatment suppressed cytotoxicity of MBP-activated T cells from rats with EAE against oligodendrocytes in culture by 66%.Astrocytes were less targeted by MBP activated T cells in vitro. |
| Mechanism/pathway | DAB(389)IL-2 directly targets CD4(+) and CD25(+) (IL-2R) T cells and effector T cell function and also indirectly suppresses the activation of macrophage CD169(+) (ED3(+)) and microglia CD11b/c (OX42(+)) populations in the CNS. |
