Basic information of Igf1 :

Official Symbol of Gene	Igf1
Species	Rattus norvegicus
Entrez Gene ID	24482
Official Full Name	insulin-like growth factor 1
Also known as	IGF
Gene Type	protein coding
dbXrefs	Ensembl:ENSRNOG00000004517 AllianceGenome:RGD:2868
Map Location	7q13
Drug	IGF-I
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	male Lewis rats
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	7541143
Year	1995
Title	Insulin-like growth factor I treatment reduces demyelination and up-regulates gene expression of myelin-related proteins in experimental autoimmune encephalomyelitis

Results of multiple sclerosis :

Result

IGF-I produced significant reductions in numbers and areas of demyelinating lesions.Relative mRNA levels for myelin basic protein, proteolipid protein (PLP), and 2',3'-cyclic nucleotide 3'-phosphodiesterase in lesions of IGF-I-treated rats were significantly higher than they were in placebo-treated rats. PLP mRNA-containing oligodendroglia also were more numerous and relative PLP mRNA levels per oligodendrocyte were higher in lesions of IGF-I-treated rats. Finally, a significantly higher proportion of proliferating cells were oligodendroglia-like cells in lesions of IGF-I-treated rats.

Mechanism/pathway

Several lines of evidence suggest that insulin-like growth factor I (IGF-I) might be useful in reducing myelin breakdown and promoting myelin regeneration in demyelinating diseases. IGF-I promotes the survival of oligodendroglia and the formation of myelin sheaths in vitro. The content of myelin also is increased in the central nervous system of transgenic mice that overexpress IGF-I.