Basic information of Plp1 :

Official Symbol of Gene	Plp1
Species	Mus musculus
Entrez Gene ID	18823
Official Full Name	proteolipid protein (myelin) 1
Also known as	jp; Plp; msd; rsh; DM20; jimpy
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000031425 AllianceGenome:MGI:97623
Map Location	X F1; X 59.1 cM
Drug	PLPfl-transduced BM
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	SJL female mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	16219491
Year	2006
Title	Bone marrow transplantation combined with gene therapy to induce antigen-specific tolerance and ameliorate EAE

Results of multiple sclerosis :

Result

The group that received BMT expressing the PLPfl construct was completely protected from disease induction. We observed massive perivascular inflammatory infiltration in the control group but not in the PLPfl-transduced BM recipients.Using this form of the therapy, we were able to block EAE progression completely in mice reconstituted with BM expressing PLPfl construct and ameliorate symptoms even after the disease symptoms had emerged.

Mechanism/pathway

Bone marrow (BM) or blood stem cell transplantation has been shown to be effective in treating severe and refractory autoimmune diseases.