Basic information of Tgfb1 :

Official Symbol of Gene	Tgfb1
Species	Mus musculus
Entrez Gene ID	21803
Official Full Name	transforming growth factor, beta 1
Also known as	Tgfb; Tgfb-1; TGFbeta1; TGF-beta1
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000002603 AllianceGenome:MGI:98725
Map Location	7 A3; 7 13.98 cM
Drug	CNS-homing gene delivery/therapy vectors based on avirulent Semliki Forest virus (SFV) expressing either native or mutant transforming growth factor beta 1 (TGF-beta1)
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	Balb/c mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	17316567
Year	2007
Title	Semliki Forest virus vectors expressing transforming growth factor beta inhibit experimental autoimmune encephalomyelitis in Balb/c mice

Results of multiple sclerosis :

Result	Both vectors, when given intraperitoneally to EAE mice significantly reduced disease severity compared to untreated mice.
Mechanism/pathway	Immunomodulation by neurotropic viral vectors may offer a promising treatment strategy for autoimmune CNS disorders.