Basic information of H2-Ab1 :

Official Symbol of Gene	H2-Ab1
Species	Mus musculus
Entrez Gene ID	14961
Official Full Name	histocompatibility 2, class II antigen A, beta 1
Also known as	IAb; Ia2; Ia-2; Abeta; H-2Ab; H2-Ab; Rmcs1; I-Abeta
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000073421 AllianceGenome:MGI:103070
Map Location	17 B1; 17 17.98 cM
Drug	monoclonal antibodies directed against the IA antigens of the MHC
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	F1 (SJL/J X BALB/c) mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	3497972
Year	1987
Title	Haplotype-specific suppression of experimental allergic encephalomyelitis with anti-IA antibodies

Results of multiple sclerosis :

Result	Antibody directed against I-As, was successful in preventing disease when therapy was begun either at the time of immunization with antigen, or following passive transfer of MBP-sensitized T cells. The mice had a delayed onset, and reduced incidence in the development of EAE.
Mechanism/pathway	Susceptibility to autoimmune disease is linked closely to the IR genes of the MHC. In vivo administration of antibody to the immune response gene products (anti-IA antibody) is effective in preventing and mitigating the course of a number of experimental autoimmune diseases including EAE.