Basic information of IFNB1 :
| Official Symbol of Gene | IFNB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3456 |
| Official Full Name | interferon beta 1 |
| Also known as | IFB; IFF; IFNB; IFN-beta |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000171855 MIM:147640; AllianceGenome:HGNC:5434 |
| Map Location | 9p21.3 |
| Drug | IFN-β-1a |
| Interaction Type | activator |
Sample information of multiple sclerosis:
| Descent | Caucasian patients |
| Disease | MS |
Literature information of multiple sclerosis :
| Pubmed ID | 20956993 |
| Year | 2010 |
| Title | Network analysis of transcriptional regulation in response to intramuscular interferon-β-1a multiple sclerosis treatment |
Results of multiple sclerosis :
| Result | We identified 121 genes that were significantly up- or downregulated compared with baseline, with stronger changed expression at 1 week after start of therapy. Eleven transcription factor-binding sites (TFBS) are overrepresented in the regulatory regions of these genes, including those of IFN regulatory factors and NF-κB. |
| Mechanism/pathway | Interferon-b (IFN-b) is currently the most established treatment for controlling the exacerbations in relapsing–remitting MS and several studies have confirmed its clinical benefit.IFN-b is a natural human pleiotropic cytokine with antiproliferative and immunomodulatory activities that is produced by various cell types including fibroblasts and macrophages. It exerts its biological effects by binding to specific cell surface receptors. |
