Basic information of Lif :

Official Symbol of Gene	Lif
Species	Mus musculus (house mouse)
Entrez Gene ID	18678
Official Full Name	eukemia inhibitory factor
Also known as	N/A
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000034394 AllianceGenome:MGI:96787
Map Location	11 A1; 11 2.94 cM
Drug	HSV-LIF vector
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	SJL/J mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	23700462
Year	2013
Title	A herpes simplex virus-derived replicative vector expressing LIF limits experimental demyelinating disease and modulates autoimmunity

Results of multiple sclerosis :

Result	The HSV-LIF significantly ameliorated the EAE and contributed to a higher number of oligodendrocytes in the brains when compared to untreated mice.The HSV-LIF therapy also induced favorable changes in the expression of immunoregulatory cytokines and T-cell population markers in the CNS during the acute disease.
Mechanism/pathway	Herpes simplex virus type 1 (HSV-1) has properties that can be exploited for the development of gene therapy vectors. LIF is a cytokine that has the potential to limit demyelination and oligodendrocyte loss in CNS autoimmune diseases and to affect the T-cell mediated autoimmune response.