Basic information of IL4 :

Official Symbol of Gene	IL4
Species	Homo sapiens
Entrez Gene ID	3565
Official Full Name	interleukin 4
Also known as	BSF1; IL-4; BCGF1; BSF-1; BCGF-1
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000113520 MIM:147780; AllianceGenome:HGNC:6014
Map Location	5q31.1
Drug	HSV-1-derived vector containing the IL-4 gene
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	9853527
Year	1998
Title	Central nervous system delivery of interleukin 4 by a nonreplicative herpes simplex type 1 viral vector ameliorates autoimmune demyelination

Results of multiple sclerosis :

Result	We found the following in treated mice: (1) delayed EAE onset, (2) a significant decrease in clinical score, (3) a significant decrease in perivascular inflammatory infiltrates and in the number of macrophages infiltrating the CNS parenchyma and the submeningeal spaces, and (4) a reduction in demyelinated areas and axonal loss.
Mechanism/pathway	CNS cytokine delivery with HSV-1 vectors is feasible and might represent an approach for the treatment of demyelinating diseases.