Basic information of NRG1 :
| Official Symbol of Gene | NRG1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3084 |
| Official Full Name | neuregulin 1 |
| Also known as | GGF; HGL; HRG; NDF; ARIA; GGF2; HRG1; HRGA; SMDF; MST131; MSTP131; NRG1-IT2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000157168 MIM:142445; AllianceGenome:HGNC:7997 |
| Map Location | 8p12 |
| Drug | rhGGF2 |
| Interaction Type | activator |
Sample information of multiple sclerosis:
| Descent | Female SJL/J mice |
| Disease | EAE |
Literature information of multiple sclerosis :
| Pubmed ID | 9707607 |
| Year | 1998 |
| Title | The neuregulin, glial growth factor 2, diminishes autoimmune demyelination and enhances remyelination in a chronic relapsing model for multiple sclerosis |
Results of multiple sclerosis :
| Result | In comparison to control groups, rhGGF2 treatment , consistently resulted in an improved clinical course, a reduction in relapse rate, lessened CNS pathology, and an increase in the amount of CNS remyelination. |
| Mechanism/pathway | RhGGF2 exerted a direct effect on either the induction or effector phase of the disease through a reduction in cell activation (lymphocytic or microglial) or modulation of cell traffic at the blood-brain barrier.And it's correlated with increased mRNA expression of myelin basic protein exon 2, a marker for remyelination, and with an increase in the CNS of the regulatory cytokine, interleukin 10, at both the RNA and protein levels. |
