Basic information of Sod3 :

Official Symbol of Gene	Sod3
Species	Mus musculus
Entrez Gene ID	20657
Official Full Name	superoxide dismutase 3, extracellular
Also known as	EC-SOD
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000072941 AllianceGenome:MGI:103181
Map Location	5 C1; 5 27.92 cM
Drug	AAV-ECSOD
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	DBA/1J mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	18055782
Year	2007
Title	Long-term suppression of neurodegeneration in chronic experimental optic neuritis: antioxidant gene therapy

Results of multiple sclerosis :

Result	These findings are suggestive of the long-term protective effect of antioxidant gene therapy against degeneration of the optic nerve induced by chronic EAE.Viral-mediated delivery of antioxidant genes provides long-lasting suppression against neuronal and axonal loss associated with permanent visual disability in patients with multiple sclerosis.
Mechanism/pathway	Reactive oxygen species (ROS) such as superoxide, hydrogen peroxide, nitric oxide, and peroxynitrite are mediators of demyelination and disruption of the blood-brain barrier (BBB) in EAE.ECSOD has been shown to offer central nervous system (CNS) neuroprotection.