Basic information of Cxcl12 :

Official Symbol of Gene	Cxcl12
Species	Rattus norvegicus (Norway rat)
Entrez Gene ID	24772
Official Full Name	C-X-C motif chemokine ligand 12
Also known as	Sdf1
Gene Type	protein coding
dbXrefs	Ensembl:ENSRNOG00000013589 AllianceGenome:RGD:3651
Map Location	4q42
Drug	Aminoguanidine (AG),a selective inhibitor of iNOS activity
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	DA rats immunized to develop EAE
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	23732617
Year	2013
Title	Nitric oxide inhibits CXCL12 expression in neuroinflammation

Results of multiple sclerosis :

Result	AG mitigated EAE and upregulated CXCL12 gene expression in SCH and MBV .Increased staining with anti-CXCL12 antibodies was determined .CXCL12-positive areas in the AG-treated group spread from cell processes deeper into the spinal cord parenchyma and structures of blood vessels were positive for CXCL12.
Mechanism/pathway	In vivo inhibition of iNOS activity sustains CXCL12 gene and protein expression and protects rats from EAE, while in vivo donation of NO inhibits CXCL12 gene expression.