Basic information of Ifnb1 :
| Official Symbol of Gene | Ifnb1 |
| Species | Mus musculus |
| Entrez Gene ID | 15977 |
| Official Full Name | interferon beta 1, fibroblast |
| Also known as | Ifb; IFNB; If1da1; IFN-beta |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000048806 AllianceGenome:MGI:107657 |
| Map Location | 4 C4; 4 41.91 cM |
| Drug | Interferon-β (IFN-β) |
| Interaction Type | activator |
Sample information of multiple sclerosis:
| Descent | C57BL/6 female mice |
| Disease | EAE |
Literature information of multiple sclerosis :
| Pubmed ID | 27373971 |
| Year | 2016 |
| Title | Evaluation of AD-MSC (adipose-derived mesenchymal stem cells) as a vehicle for IFN-β delivery in experimental autoimmune encephalomyelitis |
Results of multiple sclerosis :
| Result | Therapeutic administration of MSC-VP/IFN-β reduced the severity of disease in EAE.MSCs-VP/IFN-β downregulated the levels of IL-17 expression and upregulated the characteristic anti-inflammatory cytokine i.e., IL-10 and Treg related transcription factor, Foxp3. A robust increase in anti-inflammatory gene expression, i.e., IL-10 and downregulation of inflammatory cytokines, IL-17, was observed in mice treated with MSCs-VP/IFN-β when compared with MSCs. MSCs-VP/IFN-β treated groups increased the frequency of Treg cells. |
| Mechanism/pathway | Interferon-β (IFN-β) is commonly used as a disease modifying drug for the treatment of Relapseremitting multiple sclerosis (RR-MS). The expression of TGF-β and IL-10 under the control of IFN-β may be one of the most important mechanisms which play a critical role in the induction of Treg cells in EAE mice. |
