Basic information of FGF2 :

Official Symbol of Gene	FGF2
Species	Homo sapiens
Entrez Gene ID	2247
Official Full Name	fibroblast growth factor 2
Also known as	BFGF; FGFB; FGF-2; HBGF-2
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000138685 MIM:134920; AllianceGenome:HGNC:3676
Map Location	4q28.1
Drug	human broblast growth factor (FGF)-II gene(TH:bFGF vector)
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	C57BL/6 mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	11509953
Year	2001
Title	Fibroblast growth factor-II gene therapy reverts the clinical course and the pathological signs of chronic experimental autoimmune encephalomyelitis in C57BL/6 mice

Results of multiple sclerosis :

Result

TH:bFGF-treated mice showed a lower number of T cells and macrophages (butalso of inammatory perivascular inltrates) both in theCNS parenchyma and in the leptomeningeal space and a signicant increase of oligoden-drocyte precursors (platelet derived growth factor-receptor α(PDGFRα)+cells) in areas of demyelination andaxonal loss.A signicant decrease of the per-centage of spinal cord demyelination and axonal loss was also observed in TH:bFGF-treated mice. A signicant increase of proteolipidprotein (PLP)-expressing oligodendrocytes was also measured in TH:bFGF-treated mice .Neuropathological ndings indicate that the sustained disease-ameliorating effect observed after the treatment with the TH:bFGF vector was associated with a signi-cant decrease of the extent of CNS demyelination andaxonal loss.

Mechanism/pathway

We attribute the disease-ameliorating effect to the FGF-II-mediated recruitment into demyelinating areas of oligodendrocyte precursors located in close vicinity to or surviving within demyelinating lesions which, in turn, differentiated into myelin-forming cells.