Basic information of Ephb2 :

Official Symbol of Gene	Ephb2
Species	Mus musculus
Entrez Gene ID	13844
Official Full Name	Eph receptor B2
Also known as	Drt; Erk; Nuk; Cek5; Hek5; Qek5; Sek3; ETECK; Prkm5; Tyro5
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000028664 AllianceGenome:MGI:99611
Map Location	N/A
Drug	Broad-spectrum tyrosine kinase inhibitors Dasatinib and Vandetanib
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	mice (MGI ID 3603008)
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	32312989
Year	2020
Title	TAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response

Results of multiple sclerosis :

Result

EAE score was greatly reduced after two weeks of oral gavage of Vandetanib and Dasatinib.Vandetanib was more effective than Dasatinib in terms of EAE treatment, which may be owing to the stronger inhibition of proinflammatory gene induction by Vandetanib compared with Dasatinib. There was significantly less Th17 cells brain infiltration after Vandetanib and Dasatinib treatment, and Th17 and Th1 cell polarization were both significantly reduced in the spleen after treatment with these inhibitors.

Mechanism/pathway

inhibit EPHB2 kinase activity and EPHB2-mediated TAGAP phosphorylation