Basic information of Plp1 :

Official Symbol of Gene	Plp1
Species	Mus musculus
Entrez Gene ID	18823
Official Full Name	proteolipid protein (myelin) 1
Also known as	jp; Plp; msd; rsh; DM20; jimpy
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000031425 AllianceGenome:MGI:97623
Map Location	X F1; X 59.1 cM
Drug	hmTAP (synthetic human multitarget autoantigen protein)
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	highly specific line T cells raised from PLP139-151–primed and MOG35-55–primed SJL/J and C3H.SW mice
Disease	PLP139-151–induced EAE

Literature information of multiple sclerosis :

Pubmed ID	12093891
Year	2002
Title	Multiantigen/multiepitope-directed immune-specific suppression of "complex autoimmune encephalomyelitis" by a novel protein product of a synthetic gene

Results of multiple sclerosis :

Result	Intraperitoneal injections with hmTAP had a strong suppressive effect on PLP139-151–induced EAE, not only at the initial phase but also at the chronic stage of the disease.The effect of intravenous administration of hmTAP on PLP139-151–induced EAE in SJL/J mice was even more dramatic.
Mechanism/pathway	Abrogation is associated with inhibition of encephalitogenic T cells.