Basic information of Plp1 :
| Official Symbol of Gene | Plp1 |
| Species | Mus musculus |
| Entrez Gene ID | 18823 |
| Official Full Name | proteolipid protein (myelin) 1 |
| Also known as | jp; Plp; msd; rsh; DM20; jimpy |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000031425 AllianceGenome:MGI:97623 |
| Map Location | X F1; X 59.1 cM |
| Drug | a syngeneic fibroblast line transduced with a retroviral vector designed to encode proteolipid protein (101-157) targeted for secretion |
| Interaction Type | activator |
Sample information of multiple sclerosis:
| Descent | female SJL/J mice |
| Disease | EAE |
Literature information of multiple sclerosis :
| Pubmed ID | 14991817 |
| Year | 2004 |
| Title | Gene therapy in a murine model for clinical application to multiple sclerosis |
Results of multiple sclerosis :
| Result | Animals receiving PLP-secreting fibroblasts showed significant reductions of clinical signs.Histological studies in these mice showed either no inflammatory infiltrates or scattered perivascular or subarachnoid infiltrates, and no demyelination.The injection of PLP-secreting fibroblasts reduces the frequency and severity of EAE relapses and ameliorates the pathological destruction.Treatment of EAE mice with PLP-secreting cells results in the generation of antiinflammatory cytokines, in contrast with untreated EAE mice, which have elevated levels of IL-2 and IFN-γ. |
| Mechanism/pathway | This strategy was devised to provide a systemic, antigen-specific signal to pathogenic T cells in the absence of costimulation and, hence, render them anergic and this antigen-specific therapy acts by a cytokine-induced pathway. |
