Basic information of Hdac1 :
| Official Symbol of Gene | Hdac1 |
| Species | Mus musculus |
| Entrez Gene ID | 433759 |
| Official Full Name | histone deacetylase 1 |
| Also known as | HD1; RPD3; MommeD5; Hdac1-ps |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000028800 AllianceGenome:MGI:108086 |
| Map Location | 4 D2.2; 4 63.26 cM |
| Drug | trichostatin A (TSA) |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | C57BL/6 female mice |
| Disease | EAE |
Literature information of multiple sclerosis :
| Pubmed ID | 15885809 |
| Year | 2005 |
| Title | Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis |
Results of multiple sclerosis :
| Result | Trichostatin A (TSA) reduces spinal cord inflammation, demyelination, neuronal and axonal loss and ameliorates disability in the relapsing phase of experimental autoimmune encephalomyelitis (EAE).TSA up-regulates antioxidant, anti-excitotoxicity and pro-neuronal growth and differentiation mRNAs.TSA also inhibits caspase activation and down-regulates gene targets of the pro-apoptotic E2F transcription factor pathway.In splenocytes, TSA reduces chemotactic, pro-Th1 and pro-proliferative mRNAs. |
| Mechanism/pathway | Trichostatin A (TSA) is an inhibitor of histone deacetylase (HDAC) and histone deacetylase (HDAC) enzymes repress genes via condensation of the nucleosome and interactions with transcription factors. |
