Basic information of Lif :

Official Symbol of Gene	Lif
Species	Mus musculus (house mouse)
Entrez Gene ID	18678
Official Full Name	eukemia inhibitory factor
Also known as	N/A
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000034394 AllianceGenome:MGI:96787
Map Location	11 A1; 11 2.94 cM
Drug	lentiviral vectors (LVs) used to achieve stable expression and secretion of LIF in the CNS
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	C57Bl/6J mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	20068552
Year	2010
Title	CNS-targeted LIF expression improves therapeutic efficacy and limits autoimmune-mediated demyelination in a model of multiple sclerosis

Results of multiple sclerosis :

Result	CNS-targeted expression of LIF significantly reduced demyelination in a murine model of MS. In addition, local expression of LIF ameliorated clinical symptoms with enhanced efficacy compared to systemic treatment with recombinant protein.
Mechanism/pathway	N/A