Basic information of Mir219a-2 :

Official Symbol of Gene	Mir219a-2
Species	Mus musculus
Entrez Gene ID	723904
Official Full Name	microRNA 219a-2
Also known as	Mir219-2; Mirn219-2; mir-219a-2; mmu-mir-219a-2
Gene Type	ncRNA
dbXrefs	Ensembl:ENSMUSG00000065485 miRBase:MI0000741; AllianceGenome:MGI:3618754
Map Location	2; 2 B
Drug	miR-219
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	female C57BL/6 mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	28350989
Year	2017
Title	miR-219 Cooperates with miR-338 in Myelination and Promotes Myelin Repair in the CNS

Results of multiple sclerosis :

Result	miR-219 augmented the recovery of neurological functions in EAE Mice and exhibited a significant improvement in motor function.It appeared restoration of MBP expression in the lesions of lumbar spinal cords, which exhibit the prominent demyelinating lesions in EAE , and reduction of the demyelinated regions.
Mechanism/pathway	the presence of a higher number of CC1+ or Plp1+ OLs in the spinal lesions from miR-219-mimic-treated mice,miR-219 mimic acts as a remyelination-promoting agent to improve the clinical symptoms of EAE.