Basic information of Sirt1 :

Official Symbol of Gene	Sirt1
Species	Rattus norvegicus
Entrez Gene ID	309757
Official Full Name	sirtuin 1
Also known as	Sir2
Gene Type	protein coding
dbXrefs	Ensembl:ENSRNOG00000051592 AllianceGenome:RGD:1308542
Map Location	20p11
Drug	MAT treatment
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	Wistar rats
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	36238552
Year	2022
Title	Matrine promotes mitochondrial biosynthesis and reduces oxidative stress in experimental optic neuritis

Results of multiple sclerosis :

Result	The expression of Sirtuin 1 (SIRT1), a member of an evolutionarily conserved gene family (sirtuins), was upregulated, as well as its downstream molecules Nrf2 and PGC-1α.
Mechanism/pathway	by activating SIRT1 to regulate PGC-1α and Nrf2, which, together, promote mitochondrial biosynthesis and reduce the oxidative stress of RGCs.