Basic information of CCR6 :

Official Symbol of Gene	CCR6
Species	Homo sapiens
Entrez Gene ID	1235
Official Full Name	C-C motif chemokine receptor 6
Also known as	BN-1; DCR2; DRY6; CCR-6; CD196; CKRL3; GPR29; CKR-L3; CMKBR6; GPRCY4; STRL22; CC-CKR-6; C-C CKR-6
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000112486 MIM:601835; AllianceGenome:HGNC:1607
Map Location	6q27
Drug	fumaric acid esters
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	Homo sapiens
Disease	MS

Literature information of multiple sclerosis :

Pubmed ID	30698680
Year	2019
Title	Fumarates target the metabolic-epigenetic interplay of brain-homing T cells in multiple sclerosis

Results of multiple sclerosis :

Result	These data collectively define a direct link between fumaric acid ester treatment and hypermethylation of the MIR-21 locus in both CD4 and CD8 T cells and suggest that the immunomodulatory effect of fumaric acid esters in multiple sclerosis is at least in part due to the epigenetic regulation of the brain-homing CCR6+ CD4 and CD8 T cells.
Mechanism/pathway	the upregulation of miR-21 transcripts and CCR6 expression was inhibited