Basic information of TNF :

Official Symbol of Gene	TNF
Species	Homo sapiens
Entrez Gene ID	7124
Official Full Name	tumor necrosis factor
Also known as	DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000232810 MIM:191160; AllianceGenome:HGNC:11892
Map Location	6p21.33
Drug	IFN-b treatment
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	N/A
Disease	MS

Literature information of multiple sclerosis :

Pubmed ID	12437583
Year	2002
Title	Modulation of astrocyte inducible nitric oxide synthase and cytokine expression by interferon beta is associated with induction and inhibition of interferon gamma-activated sequence binding activity

Results of multiple sclerosis :

Result	IFN-b inhibits TNF-a, iNOS and IL-6 mRNA expression induced by IL-1/IFN-c. Pre- ()16 h), co- (0 h) and post-treatment (4 h) with IFN-b relative to the timing of IL-1/IFN-c addition show that pretreatment resulted in a greater inhibition of mRNA expression.
Mechanism/pathway	human fetal astrocytes revealed that IL-1-induced TNF-a, IL-6, as well as iNOS, are regulated by type-I and type-II IFNs.