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Basic information of Nfe2l2 :

Official Symbol of Gene Nfe2l2
Species Mus musculus
Entrez Gene ID 18024
Official Full Name nuclear factor, erythroid derived 2, like 2
Also known as Nrf2
Gene Type protein coding
dbXrefs Ensembl:ENSMUSG00000015839 AllianceGenome:MGI:108420
Map Location 2 C3; 2 44.75 cM
Drug TFM-735
Interaction Type inhibitor

Sample information of multiple sclerosis:

Descent C57BL/6 J
Disease EAE

Literature information of multiple sclerosis :

Pubmed ID 28246026
Year 2017
Title The novel Nrf2 inducer TFM-735 ameliorates experimental autoimmune encephalomyelitis in mice

Results of multiple sclerosis :

Result TFM-735 is a potent Nrf2 inducer that inhibits inflammatory cytokine production and disease progression in mice with EAE and that TFM-735 is a promising therapeutic agent for MS
Mechanism/pathway inhibits inflammatory cytokine production and disease progression