Basic information of Ascl1 :

Official Symbol of Gene	Ascl1
Species	Rattus norvegicus
Entrez Gene ID	71010
Official Full Name	achaete-scute family bHLH transcription factor 1
Also known as	Mash1
Gene Type	protein coding
dbXrefs	Ensembl:ENSRNOG00000004294 AllianceGenome:RGD:71010
Map Location	7q13
Drug	Teriflunomide
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	Wistar rat
Disease	N/A

Literature information of multiple sclerosis :

Pubmed ID	29534752
Year	2018
Title	Teriflunomide promotes oligodendroglial differentiation and myelination

Results of multiple sclerosis :

Result	Quantitative RT-PCR after 1d revealed that stimulation of primary rat OPCs with tolerated concentration profiles of teriflunomide led to a significant upregulation of CNPase, TAp73, Mash1/Ascl1, Myrf, Nkx2.2, PLP, and Sox 10 transcript levels
Mechanism/pathway	Short-term teriflunomide pulses can efficiently promote oligodendroglial cell differentiation suggesting that young, immature cells could benefit from such stimulation.