Basic information of Tnf :
| Official Symbol of Gene | Tnf |
| Species | Mus musculus |
| Entrez Gene ID | 104798 |
| Official Full Name | tumor necrosis factor |
| Also known as | DIF; Tnfa; TNF-a; TNFSF2; Tnlg1f; Tnfsf1a; TNFalpha; TNF-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000024401 AllianceGenome:MGI:104798 |
| Map Location | 17 B1; 17 18.59 cM |
| Drug | KW-2449 |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | C57BL/6 |
| Disease | experimental autoimmune encephalomyelitis |
Literature information of multiple sclerosis :
| Pubmed ID | 33155932 |
| Year | 2021 |
| Title | Anti-Inflammatory Effect of KW-2449 on Autoimmune Encephalomyelitis: An Experimental Study on Mice |
Results of multiple sclerosis :
| Result | KW-2449 also decreased TNF-α, IL-6, CCL-2 inflammatory cytokines, and MMP-2 in both brain mRNA expressions and serum levels of EAE mice |
| Mechanism/pathway | The KW-2449, aging as a multi-kinase inhibitor, modulates the inflammatory responses of cytokine cascades either in the brain or in plasma |
