Basic information of Sirt1 :

Official Symbol of Gene	Sirt1
Species	Mus musculus
Entrez Gene ID	2135607
Official Full Name	sirtuin 1
Also known as	Sir2; Sir2a; SIR2L1; Sir2alpha
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000020063 AllianceGenome:MGI:2135607
Map Location	10; 10 B4
Drug	AAV2 vectors
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	C57BL/6
Disease	experimental autoimmune encephalomyelitis

Literature information of multiple sclerosis :

Pubmed ID	29494741
Year	2018
Title	SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis

Results of multiple sclerosis :

Result	AAV2-SIRT1 mediated significant preservation of the OKR compared to AAV2-eGFP controls
Mechanism/pathway	AAV-mediated overexpression of NRF2 or SIRT1 within RGCs mediates distinct neuroprotective effects upon visual function and RGC survival