Basic information of Nfe2l2 :

Official Symbol of Gene	Nfe2l2
Species	Mus musculus
Entrez Gene ID	108420
Official Full Name	nuclear factor, erythroid derived 2, like 2
Also known as	Nrf2
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000015839 AllianceGenome:MGI:108420
Map Location	2 C3; 2 44.75 cM
Drug	AAV2 vectors
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	C57BL/6
Disease	experimental autoimmune encephalomyelitis

Literature information of multiple sclerosis :

Pubmed ID	29494741
Year	2018
Title	SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis

Results of multiple sclerosis :

Result	Treatment with AAV2-NRF2 promoted RGC survival while AAV2-SIRT1 mediated an upward trend in protection compared to vehicle and AAV2-eGFP controls
Mechanism/pathway	AAV-mediated overexpression of NRF2 or SIRT1 within RGCs mediates distinct neuroprotective effects upon visual function and RGC survival