Basic information of Esr2 :

Official Symbol of Gene	Esr2
Species	Mus musculus
Entrez Gene ID	109392
Official Full Name	estrogen receptor 2 (beta)
Also known as	ER[b]; Estrb; ERbeta
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000021055 AllianceGenome:MGI:109392
Map Location	12 C3; 12 33.52 cM
Drug	LY3201
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	SJL/J mice
Disease	experimental autoimmune encephalomyelitis

Literature information of multiple sclerosis :

Pubmed ID	23401502
Year	2013
Title	Targeting estrogen receptor β in microglia and T cells to treat experimental autoimmune encephalomyelitis

Results of multiple sclerosis :

Result	Treatment of EAE mice with LY3201, a selective ERβ agonist provided by Eli Lilly, resulted in marked reduction of activated microglia in the spinal cord
Mechanism/pathway	the ERβ-selective agonist LY3201 can inactivate microglia and invading T cells by down-regulating two important inflammatory pathways, NF-κB and iNOS