Basic information of Tnf :

Official Symbol of Gene	Tnf
Species	Rattus norvegicus
Entrez Gene ID	3876
Official Full Name	tumor necrosis factor
Also known as	Tnfa; RATTNF; TNF-alpha
Gene Type	protein coding
dbXrefs	Ensembl:ENSRNOG00000070745 AllianceGenome:RGD:3876
Map Location	20p12
Drug	GW 501516
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	N/A
Disease	experimental autoimmune encephalomyelitis

Literature information of multiple sclerosis :

Pubmed ID	19422681
Year	2009
Title	Effects of the PPAR-beta agonist GW501516 in an in vitro model of brain inflammation and antibody-induced demyelination

Results of multiple sclerosis :

Result	GW 501516 decreased the IFN-gamma-induced up-regulation of TNF-alpha and iNOS in accord with the proposed anti-inflammatory effects of this PPAR-beta agonist
Mechanism/pathway	the protective effects of PPAR-beta agonists observed in vivo can be attributed to their anti-inflammatory properties rather than to a direct protective or trophic effect on oligodendrocytes