Basic information of TGFB1 :
| Official Symbol of Gene | TGFB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 11766 |
| Official Full Name | transforming growth factor beta 1 |
| Also known as | CED; LAP; DPD1; TGFB; IBDIMDE; TGFbeta; TGF-beta1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000105329 MIM:190180; AllianceGenome:HGNC:11766 |
| Map Location | 19q13.2 |
| Drug | Simvastatin |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | RRMS |
| Disease | MS |
Literature information of multiple sclerosis :
| Pubmed ID | 23076801 |
| Year | 2013 |
| Title | Simvastatin inhibits secretion of Th17-polarizing cytokines and antigen presentation by DCs in patients with relapsing remitting multiple sclerosis |
Results of multiple sclerosis :
| Result | We report that simvastatin inhibits IL-1β, IL-23, TGF-β, IL-21, IL-12p70, and induces IL-27 secretion from DCs in RRMS patients, providing an inhibitory cytokine milieu for Th17 and Th1-cell differentiation |
| Mechanism/pathway | widely used cholesterol-lowering agents, have also been demonstrated to have antiinflammatory effects |
