Basic information of IL12A :
| Official Symbol of Gene | IL12A |
| Species | Homo sapiens |
| Entrez Gene ID | 5969 |
| Official Full Name | interleukin 2 receptor subunit beta |
| Also known as | P35; CLMF; NFSK; NKSF1; IL-12A |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000168811 MIM:161560; AllianceGenome:HGNC:5969 |
| Map Location | 3q25.33 |
| Drug | Simvastatin |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | RRMS |
| Disease | MS |
Literature information of multiple sclerosis :
| Pubmed ID | 23076801 |
| Year | 2013 |
| Title | Simvastatin inhibits secretion of Th17-polarizing cytokines and antigen presentation by DCs in patients with relapsing remitting multiple sclerosis |
Results of multiple sclerosis :
| Result | We report that simvastatin inhibits IL-1β, IL-23, TGF-β, IL-21, IL-12p70, and induces IL-27 secretion from DCs in RRMS patients, providing an inhibitory cytokine milieu for Th17 and Th1-cell differentiation |
| Mechanism/pathway | widely used cholesterol-lowering agents, have also been demonstrated to have antiinflammatory effects |
