Basic information of SOCS3 :

Official Symbol of Gene	SOCS3
Species	Homo sapiens
Entrez Gene ID	19391
Official Full Name	suppressor of cytokine signaling 3
Also known as	CIS3; SSI3; ATOD4; Cish3; SSI-3; SOCS-3
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000184557 MIM:604176; AllianceGenome:HGNC:19391
Map Location	17q25.3
Drug	Simvastatin
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	RRMS
Disease	MS

Literature information of multiple sclerosis :

Pubmed ID	18453621
Year	2008
Title	Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes

Results of multiple sclerosis :

Result	Our results demonstrated statin-mediated increases in suppressor of cytokine secretion (SOCS) 3 and suppressor of cytokine secretion 7, which negatively regulate the STAT/JAK signal transduction pathway and IL-6 and IL-23 gene expression in monocytes
Mechanism/pathway	These results provide evidence for the novel immunomodulatory mechanisms of statins, which selectively target the regulation of cytokine transcription involved in the development of the human autoimmune response