Details

Home Details


Basic information of IL4 :

Official Symbol of Gene IL4
Species Homo sapiens
Entrez Gene ID 6014
Official Full Name interleukin 4
Also known as BSF1; IL-4; BCGF1; BSF-1; BCGF-1
Gene Type protein coding
dbXrefs Ensembl:ENSG00000113520 MIM:147780; AllianceGenome:HGNC:6014
Map Location 5q31.1
Drug Simvastatin
Interaction Type activator

Sample information of multiple sclerosis:

Descent RRMS
Disease MS

Literature information of multiple sclerosis :

Pubmed ID 18453621
Year 2008
Title Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes

Results of multiple sclerosis :

Result Simvastatin also induced IFN-gamma, IL-4, and IL-27 production in monocytes, which together inhibited IL-17 transcription and secretion in CD4(+) T cells
Mechanism/pathway These results provide evidence for the novel immunomodulatory mechanisms of statins, which selectively target the regulation of cytokine transcription involved in the development of the human autoimmune response