Basic information of IL27 :

Official Symbol of Gene	IL27
Species	Homo sapiens
Entrez Gene ID	19157
Official Full Name	interleukin 27
Also known as	p28; IL30; IL-27; IL27A; IL-27A; IL27p28
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000197272 MIM:608273; AllianceGenome:HGNC:19157
Map Location	16p12.1-p11.2
Drug	Simvastatin
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	RRMS
Disease	MS

Literature information of multiple sclerosis :

Pubmed ID	18453621
Year	2008
Title	Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes

Results of multiple sclerosis :

Result	Simvastatin also induced IFN-gamma, IL-4, and IL-27 production in monocytes, which together inhibited IL-17 transcription and secretion in CD4(+) T cells
Mechanism/pathway	These results provide evidence for the novel immunomodulatory mechanisms of statins, which selectively target the regulation of cytokine transcription involved in the development of the human autoimmune response