Basic information of Sirt2 :

Official Symbol of Gene	Sirt2
Species	Mus musculus
Entrez Gene ID	64383
Official Full Name	sirtuin 2
Also known as	Sir2l; SIR2L2; 5730427M03Rik
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000015149 AllianceGenome:MGI:1927664
Map Location	7; 7 B1
Drug	NSC-based gene therapy
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	C57BL/6 mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	27344330
Year	2017
Title	LINGO-1-Fc-Transduced Neural Stem Cells Are Effective Therapy for Chronic Stage Experimental Autoimmune Encephalomyelitis

Results of multiple sclerosis :

Result	Moreover, differentiation of LINGO-1-Fc-producing NSCs into oligodendrocytes in vitro was largely diminished by an NAMPT inhibitor, indicating that LINGO-1-Fc enhances the NAMPT/NAD/Sirt2 pathway.
Mechanism/pathway	NAD then induces Sirt2, an endogenous neuroprotective factor that can promote OPC dif ferentiation.