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Basic information of Lingo1 :

Official Symbol of Gene Lingo1
Species Mus musculus
Entrez Gene ID 1915522
Official Full Name leucine rich repeat and Ig domain containing 1
Also known as LERN1; Lrrn6a; UNQ201; LINGO-1; 4930471K13Rik
Gene Type protein coding
dbXrefs Ensembl:ENSMUSG00000049556 AllianceGenome:MGI:1915522
Map Location 9; 9 B
Drug LV/Lingo-1-shRNA
Interaction Type inhibitor

Sample information of multiple sclerosis:

Descent C57BL/6
Disease experimental autoimmune encephalomyelitis

Literature information of multiple sclerosis :

Pubmed ID 25045138
Year 2014
Title Lingo-1 inhibited by RNA interference promotes functional recovery of experimental autoimmune encephalomyelitis

Results of multiple sclerosis :

Result The data showed that administering LV/Lingo-1-shRNA by ICV injection could efficiently knockdown Lingo-1 expression in vivo
Mechanism/pathway improve functional recovery and enhance myelination/remyelination