Basic information of Ifng :
| Official Symbol of Gene | Ifng |
| Species | Mus musculus |
| Entrez Gene ID | 107656 |
| Official Full Name | interferon gamma |
| Also known as | Ifg; If2f; IFN-g |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000055170 AllianceGenome:MGI:107656 |
| Map Location | 10 D2; 10 66.75 cM |
| Drug | IL-12 p40 |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | PL/J miceã€B10.PL mice |
| Disease | experimental autoimmune encephalomyelitis |
Literature information of multiple sclerosis :
| Pubmed ID | 11490028 |
| Year | 2001 |
| Title | Adoptive immunotherapy of experimental autoimmune encephalomyelitis via T cell delivery of the IL-12 p40 subunit |
Results of multiple sclerosis :
| Result | High levels of IL-12 p40 expression reduces IFN-_x005fproductionin transduced MBP-specific T cells；IL-12 p40 inhibits IFN-production in developing and effectorCD4βT cell populations |
| Mechanism/pathway | These data suggest that IL-12 p40can act therapeutically by interrupting Th1-mediated inflammatoryautoimmune responses |
