Basic information of IFNAR1 :
| Official Symbol of Gene | IFNAR1 |
| Species | Homo sapiens |
| Entrez Gene ID | 5432 |
| Official Full Name | interferon alpha and beta receptor subunit 1 |
| Also known as | AVP; IFRC; IFNAR; IFNBR; IMD106; IFN-alpha-REC |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000142166 MIM:107450; AllianceGenome:HGNC:5432 |
| Map Location | 21q22.11 |
| Drug | IFN-β |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | N/A |
| Disease | MS |
Literature information of multiple sclerosis :
| Pubmed ID | 27346865 |
| Year | 2016 |
| Title | Immune response genes receptors expression and polymorphisms in relation to multiple sclerosis susceptibility and response to INF-β therapy |
Results of multiple sclerosis :
| Result | There was a significant decrease of IFNAR1 and IFNAR2 mRNA expression and a significant increase of CCR5 mRNA expression in MS patients compared with the control group |
| Mechanism/pathway | It exerts its effect by reducing T-cell activation, inhibiting IFN-γ effects and the blood–brain barrier leakage, and inducing an immune deviation, either by inhibiting T helper-1 (Th-1) or by promoting T helper-2 (Th-2) cytokines production |
