Basic information of Nampt :

Official Symbol of Gene	Nampt
Species	Mus musculus
Entrez Gene ID	59027
Official Full Name	nicotinamide phosphoribosyltransferase
Also known as	Pbef; Pbef1; Visfatin; NAmPRTase; 1110035O14Rik
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000020572 AllianceGenome:MGI:1929865
Map Location	12; 12 A3
Drug	NSC-based gene therapy
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	C57BL/6 mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	27344330
Year	2017
Title	LINGO-1-Fc-Transduced Neural Stem Cells Are Effective Therapy for Chronic Stage Experimental Autoimmune Encephalomyelitis

Results of multiple sclerosis :

Result	Moreover, differentiation of LINGO-1-Fc-producing NSCs into oligodendrocytes in vitro was largely diminished by an NAMPT inhibitor, indicating that LINGO-1-Fc enhances the NAMPT/NAD/Sirt2 pathway.
Mechanism/pathway	Through binding to the TrkB receptor, BDNF induces NAMPT, a rate-limiting enzyme involved in the conversion of nicotinamide into NAD.