Basic information of Tnf :

Official Symbol of Gene	Tnf
Species	Rattus norvegicus
Entrez Gene ID	3876
Official Full Name	tumor necrosis factor
Also known as	Tnfa; RATTNF; TNF-alpha
Gene Type	protein coding
dbXrefs	Ensembl:ENSRNOG00000070745 AllianceGenome:RGD:3876
Map Location	20p12
Drug	Piperine
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	female Lewis rats
Disease	experimental autoimmune encephalomyelitis

Literature information of multiple sclerosis :

Pubmed ID	34338970
Year	2021
Title	Piperine Improves Experimental Autoimmune Encephalomyelitis (EAE) in Lewis Rats Through its Neuroprotective, Anti-inflammatory, and Antioxidant Effects

Results of multiple sclerosis :

Result	Gene expression analysis in lumbar spinal cord showed that piperine treatment decreased the level of pro-inflammatory cytokines (TNF-α, IL-1β) and iNOS and enhanced IL-10, Nrf2, HO-1, and MBP expressions
Mechanism/pathway	the efficiency of piperine on progression of EAE model and myelin repair mechanisms was investigated