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Basic information of Olig2 :

Official Symbol of Gene Olig2
Species Mus musculus
Entrez Gene ID 1355331
Official Full Name oligodendrocyte transcription factor 2
Also known as RK17; Olg-2; Bhlhb1; Oligo2; bHLHe19
Gene Type protein coding
dbXrefs Ensembl:ENSMUSG00000039830 AllianceGenome:MGI:1355331
Map Location 16 C3.3; 16 52.6 cM
Drug Carvacrol
Interaction Type activator

Sample information of multiple sclerosis:

Descent Lewis rats
Disease experimental autoimmune encephalomyelitis

Literature information of multiple sclerosis :

Pubmed ID 36580874
Year 2022
Title Effect of Carvacrol on histological analysis and expression of genes involved in an animal model of multiple sclerosis

Results of multiple sclerosis :

Result Carvacrol administration significantly reduced the expression of IL-1, IL-17, and NF-κB and increased MBP and OLIG2 expression
Mechanism/pathway Increased OLIG2 expression also increases the production of differentiated oligodendrocytes and leads to premature CNS myelination