Basic information of Nfe2l2 :

Official Symbol of Gene	Nfe2l2
Species	Mus musculus
Entrez Gene ID	108420
Official Full Name	nuclear factor, erythroid derived 2, like 2
Also known as	Nrf2
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000015839 AllianceGenome:MGI:108420
Map Location	2 C3; 2 44.75 cM
Drug	spinal cord
Interaction Type	N/A

Sample information of multiple sclerosis:

Descent	C57BL/6
Disease	experimental autoimmune encephalomyelitis

Literature information of multiple sclerosis :

Pubmed ID	21354971
Year	2011
Title	Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

Results of multiple sclerosis :

Result	In mice deficient for nuclear factor (erythroid-derived 2)-related factor 2 on the same genetic background, the dimethylfumarate mediated beneficial effects on clinical course, axon preservation and astrocyte activation were almost completely abolished thus proving the functional relevance of this transcription factor for the neuroprotective mechanism of action.
Mechanism/pathway	where dimethylfumarate applicationmay lead to direct Nrf2 activation, not only in different neuronalpopulations, but also in oligodendrocytes and astrocytes