Basic information of S1pr1 :

Official Symbol of Gene	S1pr1
Species	Mus musculus
Entrez Gene ID	29733
Official Full Name	sphingosine-1-phosphate receptor 1
Also known as	N/A
Gene Type	protein coding
dbXrefs	Ensembl:ENSRNOG00000013683 AllianceGenome:RGD:61958
Map Location	2q41
Drug	Ponesimod
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	C57Bl/6J
Disease	experimental autoimmune encephalomyelitis

Literature information of multiple sclerosis :

Pubmed ID	34986275
Year	2022
Title	Ponesimod inhibits astrocyte-mediated neuroinflammation and protects against cingulum demyelination via S1P1 -selective modulation

Results of multiple sclerosis :

Result	These data support the CNS activities of ponesimod through S1P1 , including protective, and likely selective, effects against demyelination in a major connection pathway of the brain, the limbic fibers of the cingulum, lesions of which have been associated with several neurologic impairments including MS fatigue.
Mechanism/pathway	Ponesimod is a sphingosine 1-phosphate (S1P) receptor (S1PR) modulator that was recently approved for treating relapsing forms of multiple sclerosis (MS).