Basic information of Il17a :

Official Symbol of Gene	Il17a
Species	Mus musculus
Entrez Gene ID	16171
Official Full Name	interleukin 17A
Also known as	Il17; Ctla8; IL-17; Ctla-8; IL-17A
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000025929 AllianceGenome:MGI:107364
Map Location	1; 1 A4
Drug	CpdA
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	C57BL/6J
Disease	experimental autoimmune encephalomyelitis

Literature information of multiple sclerosis :

Pubmed ID	19997594
Year	2009
Title	Therapeutic and adverse effects of a non-steroidal glucocorticoid receptor ligand in a mouse model of multiple sclerosis

Results of multiple sclerosis :

Result	Administration of high-dose CpdA to mice was lethal while treatment of EAE with low to intermediate amounts of CpdA dissolved in water significantly ameliorated the disease
Mechanism/pathway	The beneficial effect of CpdA required expression of the GR in T cells and was achieved by down regulating LFA-1 and CD44 on peripheral Th cells and by repressing IL-17 production.