Basic information of Il4 :

Official Symbol of Gene	Il4
Species	Mus musculus
Entrez Gene ID	16189
Official Full Name	interleukin 4
Also known as	Il-4; BSF-1
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000000869 AllianceGenome:MGI:96556
Map Location	11 B1.3; 11 31.97 cM
Drug	the IL-4 gene-containing vector
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	Biozzi AB/H
Disease	experimental autoimmune encephalomyelitis

Literature information of multiple sclerosis :

Pubmed ID	11402297
Year	2001
Title	Central nervous system gene therapy with interleukin-4 inhibits progression of ongoing relapsing-remitting autoimmune encephalomyelitis in Biozzi AB/H mice

Results of multiple sclerosis :

Result	Our results, showing that IL-4 gene delivery using HSV-1 vectors induces protection from EAE by in situ modulating the cytokine/chemokine-mediated circuits sustaining effector cell functions, indicate that the intrathecal 'therapeutic' use of nonreplicative HSV-1-derived vectors containing anti-inflammatory molecules might represent an alternative strategy in inflammatory diseases of the CNS.
Mechanism/pathway	Our results, showing that IL-4 gene delivery using HSV-1 vectors induces protection from EAE by in situ modulating the cytokine/chemokine-mediated circuits sustaining effector cell functions, indicate that the intrathecal 'therapeutic' use of nonreplicative HSV-1-derived vectors containing anti-inflammatory molecules might represent an alternative strategy in inflammatory diseases of the CNS.