Basic information of Il17a :

Official Symbol of Gene	Il17a
Species	Mus musculus
Entrez Gene ID	16171
Official Full Name	interleukin 17A
Also known as	Il17; Ctla8; IL-17; Ctla-8; IL-17A
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000025929 AllianceGenome:MGI:107364
Map Location	1; 1 A4
Drug	dimethyl fumarate (DMF)
Interaction Type	N/A

Sample information of multiple sclerosis:

Descent	C57BL/6J
Disease	experimental autoimmune encephalomyelitis

Literature information of multiple sclerosis :

Pubmed ID	31844089
Year	2019
Title	IL-17 CD8 T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis ++

Results of multiple sclerosis :

Result	herapeutic DMF application significantly reduced EAE severity, reflected by reduced T cell and CD8 T cell numbers, as well as by decreased frequency of Tc17 cells in the CNS
Mechanism/pathway	ence, DMF treatment caused a loss of the Tc17-dependent Th17 pathogenicity and conferred a stable “low IL-17” phenotype to Tc17 cells, suggesting a mechanism for amelioration of autoimmunity in CNS upon DMF treatment.