Basic information of TNFSF10 :

Official Symbol of Gene	TNFSF10
Species	Homo sapiens
Entrez Gene ID	8743
Official Full Name	TNF superfamily member 10
Also known as	TL2; APO2L; CD253; TANCR; TRAIL; Apo-2L; TNLG6A
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000121858 MIM:603598; AllianceGenome:HGNC:11925
Map Location	3q26.31
Drug	interferon-beta therapy
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	N/A
Disease	MS

Literature information of multiple sclerosis :

Pubmed ID	12814715
Year	2003
Title	TNF-related apoptosis inducing ligand (TRAIL) as a potential response marker for interferon-beta treatment in multiple sclerosis

Results of multiple sclerosis :

Result	Our results showed that in patients with multiple sclerosis, expression of both MxA and TRAIL in peripheral blood mononuclear cells increased significantly both in the immediate short term, and in the long term after treatment with interferon beta.
Mechanism/pathway	Our findings of an early and sustained induction of TRAIL expression in patients with multiple sclerosis responding to interferon-beta therapy now clearly shows that this ligand is involved in the immunoregulatory processes of this drug